Retatrutide

Retatrutide has a blood half-life of about 7 days, making it suitable for weekly injections.

Weeks 1–4 — 1 mg

Weeks 5–8 — 2 mg

Weeks 9–12 — 4 mg

Weeks 13–16 — 6 mg

From week 17 — 8–12 mg

Injection site: Inject into your abdomen, thigh or upper arm

Retatrutide is a triple receptor agonist that activates GLP-1, GIP, and glucagon receptors. By combining these pathways, it improves insulin secretion, lowers blood glucose, reduces appetite, and increases calorie burning through a higher metabolic rate. It is used for type 2 diabetes management, long-term weight control, and aggressive fat loss protocols.

Short term - Lyophilized peptides will remain stable at room temperature for 30-60 days. However, upon receipt all peptides should be stored in the refrigerator (under 4C (39F) for maximum stability and longevity. Peptides stored at this temperature can last 1-2 years.

Long term - If you are not going to use the peptides withing 1-2 months it is preferable to store the peptides in a freezer at -18C (0F). Peptides stored at this temperature can last 2-3 years. Even more preferable for long term storage is freezing at -80C (-112F) in order to preserve the peptides stability long term.

Short term - Peptide solutions generally remain stable up to 30 days when stored in the refrigerator at 4C (39F) depending on the length of the peptide sequence and its inherent instability factors.

Long term - If peptides absolutely must be stored in solution, sterile buffers at pH 5-6 should be used if possible, and the peptide solution should be separated into aliquots to avoid repeated freezing and thawing. Freezing at -80C (-112F) is optimal in order to preserve the peptides stability.

• Protein intake: 1.6–2.2 g per kg of body weight

• Regular strength training

• Electrolyte monitoring

• Monitor total calorie intake

• Fiber: 25–40 g per day

• Adequate water intake

• Avoid large high-fat meals, as they may increase nausea

• Electrolytes

• Magnesium

• Omega-3

• Vitamin D

For people with diabetes or high risk

Every 3–6 months:

• HbA1c

• Glucose

• Insulin

Also monitor:

• Lipid profile

• Liver enzymes

For healthy individuals using Retatrutide for weight loss

• Glucose and insulin — every 6–12 months

• Lipid profile — every 6–12 months

• Liver enzymes — periodically during long-term use

(especially if there is fatty liver or other risk factors)